Adenomatoid odontogenic tumor (AOT), a benign (hamartomatous) lesion of odontogenic origin, is an uncommon tumor which affects mainly. Adenomatoid odontogenic tumor (AOT) is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. To acquire additional. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. It appears mostly in young patients and females, the maxillary.

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Extra oral examination There is diffused swelling involving right anterior maxilla with moderate obliteration of nasolabial fold [ Figure 1 ]. Some authorities feel that, given the slow growth and circumscription of the lesion, it is best classified as a hamartoma rather than a true neoplasm [ 3 ]. In one of the tumors, occasional cell foci with a squamous appearance were observed.

Review of the literature and report of a rare case.

Mandibular adenomatoid odontogenic tumor: Radiographic and pathologic correlation

The characteristic duct-like structures are lined by a single row of columnar epithelial adenomattoid, the nuclei of which are polarized away from the central lumen, as was evident in all our cases. This lesion is most commonly associated with an impacted maxillary canine. Philipsen and Reichart 14 considered AOT a non-invasive slow-growing benign lesion hamartomatous.

Radiographic findings Well-circumscribed radiolucent lesion same in odontogeinc maxilla with impacted teeth 13 and 14, with well-defined radio-opaque border. It should be emphasized that although AOT is very rare, careful diagnosis and adequate interpretation of clinical and radiographic findings may be helpful in arriving at a correct diagnosis.


H and E stained section showing Dentigerous cyst lining and the typical appearance of AOT with tubules, spindle cells and plexiform cords Click here to view. The surgical specimen may be solid or cystic. Please review our privacy policy. Adenomatoid odontogenic tumor associated with dentigerous cyst of the maxillary daenomatoid On radiographsthe adenomatoid odontogenic tumor presents as a radiolucency dark area around an unerupted tooth extending past the cementoenamel junction.

In addition, the use of lyophilized bone and guided tissue regeneration are recommended in large osseous cavities. We had an interesting CK14 immunohistochemical profile.

Adenomatoid odontogenic tumor – Wikipedia

The spindled structures, adenimatoid the duct-like and adenomatoid structures were located, would form a cell group analogous to post-secretory ameloblasts of the reduced enamel epithelium, surrounded by a second group, constituted by flat fusiform cells, sometimes with morphology similar to that of the stellate reticulum. Primary closure of lesion Click here to view. The surgical management of this tumor should be enucleation along with the associated impacted tooth and simple curettage.

The extraction of the impacted left maxillary canine was recommended due to its buccal position and absence of the vestibular cortical bone as shown on a Cone Beam Computerized Tomography CBCT Figure 1. The epithelium with columnar cells followed this pattern, with rare positive suprabasal cells Figure 6.

In the AOT, PCNA revealed that the cells in the spindled areas and in the peripheral oodntogenic were the most proliferative, which could suggest that those sites would be responsible for the tumoral growth. Follicular adenomatoid odontogenic tumor: Two thirds of the cases are associated with an impacted tooth usually being the canine. An apical cyst is usually associated with an endodontic-treated or mortified pulp tooth, but in this case, the teeth 21 and 24 were positive to cold sensitivity test.


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The adenomatoid odontogenic tumor: AOT has cytological features similar to various components of enamel organ, dental lamina, reduced enamel epithelium, and its remnants. The purpose of this article is to report and analyze four unusual cases of AOT located in the mandible, with an emphasis on radiographic findings and with pathologic correlation, and to review the existing literature on this tumor.

Stern, Oral and Maxillofacial Pathology: Gross and histological examination of 45 cases. J Oral Maxillofac Pathol. View at Google Scholar K. It may present as a solid mass, a single large cystic space, or as numerous small cystic spaces.

Mandibular adenomatoid odontogenic tumor: Radiographic and pathologic correlation

Two thirds of cases are located in the anterior maxillaand one third are present in the anterior mandible. Such characteristics are similar to those of the reduced enamel epithelium REE in the protective and maturation stage of amelogenesis, which led us to work on the hypothesis tumr the origin of AOT from it.

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