Hypogonadisme hypogonadotrope: notions récentes sur la régulation de l’axe hypothalamo-hypophyso-gonadiqueHypogonadotropic hypogonadism: new. Troubles de l’axe hypothalamo-hypophyso-ovarien chez la femme alcoolique Queval D, Delcroix MExploration de l’axe hypothalamo gonadique chez les. (ré)activation de l’axe hypothalamo-hypophyso-gonadique conduit à une série de changements physiques aboutissant à la maturation et au maintien d’un.

Author: Kezshura Yozshushicage
Country: Moldova, Republic of
Language: English (Spanish)
Genre: Life
Published (Last): 7 May 2016
Pages: 485
PDF File Size: 17.31 Mb
ePub File Size: 8.75 Mb
ISBN: 856-5-78921-597-2
Downloads: 96361
Price: Free* [*Free Regsitration Required]
Uploader: Akisar

Hypogonadotropic hypogonadism HH is defined by the absence of sex steroid synthesis associated with the lack of appropriate gonadotrophin secretion. This leads to a variable degree of impuberism, often diagnosed during childhood or adolescence.

Genetics of HH involve many genes. Kallmann syndrome KS is defined by the association of HH and anosmia. However, genetics of KS is complex, because of the variability of the phenotype for a gonadiquee molecular defect.

Otherwise, heterozygous anomalies are frequently described.

À propos de l’exploration de l’axe hypothalamo-hypophyso-gonadique – EM|consulte

Identification in the same patient of several mutations in some of these genes digenism could account for this variability. Autosomal recessive transmission is frequently observed in familial cases of HH without anosmia. Molecular alterations have been identified for several neuropeptides or their corresponding receptors, which are involved in the physiology of the gonadotropic axis: Anomalies of leptin or its receptor are also involved in HH cases.


A new negative regulating element has been recently hypotahlamo in humans: Recent progress about these hhpothalamo leads to a new model of comprehension of the gonadotropic axis physiology, from a linear model to a network model, which regulates the central element of regulation of the gonadotropic axis, represented by the GnRH neurons.

Médecine de la Reproduction

Journal page Archives Sommaire. Access to the text HTML. Access to the PDF text If you experience reading problems with Firefox, please follow this procedure.

Bouvattier 2M. Outline Hypothalajo le plan.

The full text of this article is available in PDF format. Click here to see it. Top of the page – Article Outline. Non-syndromic congenital hypogonadotropic hypogonadism: Bonadique possible role for reproductive hormones in newborn boys: The complex genetics of Kallmann syndrome: Genetic analysis in patients with Kallmann syndrome: Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: J Clin Endocrinol Metab June 23 [in press].


X-linked congenital hypohpyso hypoplasia: Clinical Approach to Hypogonadotropic Hypogonadism Endocrine 92 nd annual meeting: Management of Hypogonadism through Puberty Endocrine 92 nd annual meeting: Normosmic Isolated Hypogonadotropic Hypogonadism: Contact Help Who are we?

As per the Law relating to information storage and personal integrity, you have the right to oppose art 26 of that lawaccess art 34 gpnadique that law and rectify art 36 of that law your personal data.

You may thus request that your data, should it be inaccurate, incomplete, unclear, outdated, not be used or stored, be corrected, clarified, updated or deleted. Personal information regarding our website’s visitors, including their identity, is confidential.

Hupophyso owners of this website hereby guarantee to respect the legal confidentiality conditions, applicable in France, and not to disclose this data to third parties.

You can move this window by clicking on the headline.