CLASSIFICATION OF ANTIHYPERLIPIDEMIC DRUGS PDF

Antihyperlipidemic Drugs. c h a p t e r atherosclerosis bile acid sequestrants catalyst cholesterol high-density lipoproteins (HDL). HMG-CoA. Hypolipidemic agents, or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are used in the treatment of high levels of fats (lipids), such as cholesterol, in the blood (hyperlipidemia). They are called lipid-lowering drugs . Contents. 1 Classes. Established. 2 Research; 3 References; 4 See also. Chapter 18 Antihyperlipidemic Agents LEARNING OBJECTIVES Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics.

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Considerable evidence points to oxidation of LDL as an essential step in the development of atheromaand therefore interest has centred on the role of either endogenous or therapeutic vitamin E in prevention of atheroma. Describe some antihyperlipidemics obtained from fermentation process. Alpha- tocopherol acetate vitamin E Omega-3 marine triglycerides Maxepa Orlistat.

Excretion takes place through the bile and feces some urinary elimination also occurs. Decongestants Bronchodilators Cough medicines H 1 antagonists. They may differ in both their impact on the cholesterol profile and adverse effects.

Chapter Antihyperlipidemic Agents – Medicinal Chemistry, 2nd Edition [Book]

Lipid disorders Disorders of lipid metabolism are manifest by elevation of the plasma concentrations of the various lipid and lipoprotein fractions total and LDL cholesterol, VLDL, triglycerides, chylomicrons and they result in cardiovascular disease and atherosclerosis deposition of fats at walls of arteries, forming plaque PowerPoint Presentation: Anhihyperlipidemic, warfarindigoxinthiazide diuretics, phenobarbitone and thyroid hormones should be taken 1 h-2h before or 4 h-6h after colestyramine to avoid impairment of their absorption Because the drug binds anions.

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Vaxelis Vaxelis is a hexavalent combination vaccine indicated for active immunization Antidotes Contrast media Radiopharmaceuticals Dressings Senotherapeutics. Define hyperlipidemia and atherosclerosis, and their causes Classify antihyperlipidemics based on the structure antihyperlilidemic mode of action Define HMG-CoA and its role in hyperlipidemia Define the pharmacophoric requirements of the druggs class of antihyperlipidemics Describe some antihyperlipidemics obtained from fermentation process Describe the cholesterol biosynthetic pathway and its significance Define PPAR?

By reducing the LDL cholesterol, they can prevent both the primary and secondary symptoms of coronary heart disease. In treatment of type IIA and IIB hyperlipidemias along with statins when response to statins is inadequate or they are contraindicated.

Lipid-lowering agent

Because these drugs increase biliary cholesterol excretion, there is a predisposition to the formation of gallstones. Fibric acid derivatives may induce a Myopathy and rhabdomyolysis the risk is greater in: Plasma total cholesterol and LDL-cholesterol fall to attain a maximum effect 1 month after therapy.

Orally given but neither absorbed nor metabolically altered by intestine, totally excreted in feces. Mechanism of action of statins PowerPoint Presentation: This page was last edited on 23 Februaryat The most severe hyperlipidaemias usually occur In patients with concurrent conditions, e.

Nicotinamide alone does not decrease plasma lipid levels.

Get unlimited access to videos, live online training, learning paths, books, tutorials, and more. Automatically changes to Flash or non-Flash embed. Classigication marine triglycerides Maxepa contain the triglyceride precursors of two polyunsaturated fatty acids derived from oily fish.

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Anti Hyperlipidemic Drugs DrNajlaa. Hyperuricemia and gout Niacin inhibits tubular secretion of uric acid Impaired glucose tolerance Hepatotoxicity.

Fibrates enhance the effect of co-administered oral Anticoagulants. By clicking Subscribe, I agree to the Drugs. Niacin is administered orally. Type of hyperlipidemia Primary hyperlipidemia Secondary hyperlipidemia. Patients with poor renal Function In patients taking a statin. Anti Hyperlipidemic Drugs Dr. Adverse effect of statins: This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.

Therefore, it is particularly useful in the treatment of familial hyperlipidemias.

Lipid-lowering agent – Wikipedia

Some antihyperlipidemic agents aim to lower the levels of low-density lipoprotein LDL cholesterol, some reduce triglyceride levels, and some help raise the high-density classiflcation HDL cholesterol. Antihyperlipidemic agents promote reduction of lipid levels in the blood.

Colesevelam has fewer gastrointestinal side effects and not Impaired absorptions PowerPoint Presentation: Secondary hyperlipidaemias results from: Classify antihyperlipidemics based on the structure and mode of action. At high doses, cholestyramine and colestipol impair the absorption of the fat-soluble vitamins A, D, E, and K.