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The political occupation of management positions creates conflicts and demotivation among team members and their managers, hindering the culture of trust that the production and the sharing of knowledge 57077. American Chemical Society ; Slides were lightly counterstained with hematoxylin, dehydrated, and mounted using histologic mounting media, Histomount National Diagnostics. However, users may ,ei, download, or email articles for individual use.

Coordinated expression of galectin-3 and galectinbinding sites in malignant mammary tumors: The decreot on individual competencies could indicate reductionism in the management model or the use of tools and techniques that prove to be isolated and derceto with the strategic conception necessary to the management model.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. In solid tumors, hypoxia is primarily a drcreto consequence of the high tumor growth with lagging angiogenesis, and is one of the major stress sources for both cancer and normal cells [ 182425 ].

Necrotic areas are often invaded by polymorphonuclear infiltrates [ 58 ]. Our previous studies demonstrated that the expression of galectin-3 and galectinbinding sites is dynamic and seems to be, at least in part, microenvironment-related [ 7 ]. Open in a separate window. Characterization of four in vitro established canine mammary carcinoma and one atypical benign mixed tumor cell lines.

In this study we report that galectin-3 expression is associated with lwi microenvironment hypoxia in canine mammary cancer cells.

In order to investigate if oxygen deprivation would be a steering factor underlying galectin-3 expression and function in spontaneously occurring mammary tumors, a small series of metastatic CMT was examined. Galectin-3 and MUC1 were expressed in tumor cells around necrosis. Ruas decretoo Silva and Mello point out that socioeconomic factors such as economic instability, low predictability of the company-market and company-client relationship, besides the intensification of customization strategies generate new forms of work organization, transitioning from stability and predictability to a differentiated and fluid condition.


Thus, the mechanisms that regulate galectin-3 expression in neoplastic settings are not clear. RAP, 47 6 It is important to highlight, however, the limitations of this study, considering that the area responsible for implementing the model in the organization was the provider of the information about the model and functioning of the work groups, possibly compromising the impartiality of the information provided.

The gap between organizational discourse, which advocates teamwork, cooperation between peers and sectors of the organization, and management practices, which focus on the individual, reveals an organizational daily life marked by contradictions and polarities.

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In malignant CMT cells, hypoxia was observed to induce expression of galectin-3, a phenomenon that was almost completely prevented by catalase treatment of CMT-U27 cells. In addition, the Management Report of the UFPB indicates factors that corroborate that with the information provided by the employees and its articulation with the strategic objectives of the institution.

In situ hybridization confirmed that galectin-3 transcription was in fact increased in the tumor cells from hypoxic regions. Among the outlined strategic objectives, those related to the People and Technology perspective can be directly associated with the Competency-based Management Model, adopted by the institution as one of its management strategies linked to the adequacy to the PNDP, focusing on the continuous development of the public servant.

The author considers the first view as that of strategic management, related to the application of the concept at the macro level of management, whose essential competencies would be at the core of the discussions.

Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis

Ten face-to-face interviews were conducted with variable duration between the interviewees. This early response could further be explained by the previous demonstration that GLUT-1 is a direct transcriptional target of HIF1, which rapidly increases upon any hypoxic pulse.

According to Michauxthe action deserves to be highlighted because the concept of competency has a dynamic character and involves the mobilization of resources in order to act. Journal of clinical oncology: Evidence was collected from documentary analysis and semi-structured interviews with ten employees from dedreto respective Personnel Management areas.

Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis

In order for the management model to be a strategy of organizational le, as discussed by Silva and Mellothe development of the employees should occur according to management needs. Regarding the third hypothesis, galectin-3 is regulated by MUC1 through microRNA in human cells, in a glycosylation-dependent manner [ 52 ].


Although lfi normoxic conditions hydrogen peroxide induced an apparent increase of decerto heavier molecular weight form of galectin-3, such effect was not observed under hypoxia.

Currently, two out of the four subsystems mentioned are in place: Likewise, no differences were found in the expression of galectin-3 when CMT-U27 cells were treated with a proteasome inhibitor, either in normoxic or in hypoxic conditions S3 Fig. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Ohtsubo K, Marth JD.

RAP, 34 3 We observed that galectin-3 mRNA was increased upon low oxygen exposure, demonstrating that the gene was transcriptionally activated under hypoxic conditions. Breast cancer research and treatment. Galectin-3 might be an interesting target to overcome this [ 67 ].

In hypoxic conditions, upon medium detoxification, galectin-3 expression decreased when compared with hypoxic untreated CMT-U27 cells Fig 2Bcorroborating the immunofluorescence analyses. Based on these results, we propose a model to reconcile the overexpression of galectin-3 in necrosis surrounding areas of canine mammary cancer lesions and suggest that this might be a critical player in metastasis.

Regarding organizational aspects, Table 3 summarizes the interviewees’ perceptions and, although it is possible to identify the concern of the organizations with the construction of effective work groups, there is a diversity of postures regarding the existence of formal aspects that contributes to the commitment on the part of the employees. Esclarecendo a teoria dos recursos e do capital social.

The core competence of the corporation. The model is considered strategic as it imparts integrative action to people management practices that would be directly linked to the strategic objectives of the institution. Cytoplasmic galectin-3 localization is increased under hypoxic conditions Galectin-3 actions rely on its subcellular location and on the phenotype of the cell itself, ranging from a pro-apoptotic function effect when present in the nucleus, to an anti-apoptotic one when in the cytoplasm [ 37 ].